Executive Order 14336

Ensuring American Pharmaceutical Supply Chain Resilience by Filling the Strategic Active Pharmaceutical Ingredients Reserve

Signed 2025-08-13 in effect
HealthcareNational SecurityPharmaceuticals
Trade & TariffsForeign Policy & National SecurityHealth

Directs the filling of the Strategic Active Pharmaceutical Ingredients Reserve (SAPIR) with active pharmaceutical ingredients and finished doses for the most critical medicines, produced domestically.

Section by Section

What each section does, and how they differ.

Sec. 1 Purpose

Addresses pharmaceutical supply chain resilience by using the Strategic Active Pharmaceutical Ingredients Reserve (SAPIR) to maintain supplies of critical active pharmaceutical ingredients and finished drugs.

Sec. 2 Filling the SAPIR with APIs for the Most Critical Medicines

Directs ASPR to develop a list of approximately 26 critical drugs and source or manufacture active pharmaceutical ingredients to fill the SAPIR within specified timelines using available funding.

Sec. 3 Ensuring SAPIR Resilience

Requires ASPR to update its essential medicines list and coordinate with agencies to maintain pharmaceutical supply chain capabilities for national security.