Executive Order 14292

Improving the Safety and Security of Biological Research

Signed 2025-05-05 in effect
BiosecurityScienceNational Security
Foreign Policy & National SecurityTechnology & Innovation

Directs enhanced safety protocols for federally funded biological research, including gain-of-function research oversight.

Section by Section

What each section does, and how they differ.

Sec. 1 Purpose

Establishes commonsense oversight of dual-use biological research and gain-of-function studies.

Sec. 2 Policy

OSTP to revise oversight policy ensuring research transparency and public accountability.

Sec. 3 Dual-Use Research Oversight

Agencies to implement federal funding requirements and compliance audits for dangerous research.

Sec. 4 Secure Future Research Through Commonsense Frameworks

OSTP to revise dual-use research policy by 120 days; strengthen oversight, enforcement, and transparency on gain-of-function research.

Sec. 5 Manage Risks Associated with Non-federally Funded Research

OSTP to develop strategy within 180 days governing non-federally funded dangerous research and nucleic acid synthesis screening.

Sec. 6 Increase Accountability and Public Transparency of Dangerous Gain-of-Function Research

OSTP to ensure reporting mechanism for federally funded dangerous research; publicly available information on programs and awards.

Sec. 7 Future Enforcement Terms

HHS to include compliance terms in research contracts and grants requiring certification against dangerous research.